Program Head, Diabetes, Metabolism & Clinical Sciences
MBBs MRCP ( Edin ) FRACP FARM PhD
Professor Jane Valentine is a senior consultant paediatrician at Perth Children’s Hospital and Head of Research for Kids Rehab WA and for the years 2004-2019 was the Head of Department, Kids Rehab WA. She leads a clinically integrated research unit with an established consumer reference group. Her research work focuses on translation to improve outcomes for Children and their families with direct impact on policy and practice.
Professor Valentine was part of the international team that in 2017 published the international guidelines for the early detection of Cerebral Palsy (CP) and recently the International Clinical Practice Guideline Based on Systematic Reviews for early intervention for children with or at risk of CP. This has led her to establish with her team the at-risk CP clinical early intervention clinic, ensuring early diagnosis and early evidence-based intervention and entry into NHMRC funded trials for babies with CP and most importantly improved outcomes for the child and their family.
Professor Valentine has also published extensively on the short and long-term outcomes of children and adolescents with Cerebral Palsy (CP) treated with Botulinum toxin .
Professor Valentine is the Co-Lead, Early Moves NHMRC Clinical Trials and Cohort Study, a large scale cohort study to identify early biomarkers for cognitive impairment.
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Publications
May 2023
Clinical Phenotype in Individuals With Birk-Landau-Perez Syndrome Associated With Biallelic SLC30A9 Pathogenic Variants
Birk-Landau-Perez syndrome is a genetic disorder caused by biallelic pathogenic variants in SLC30A9 presenting with a complex movement disorder, developmental regression, oculomotor abnormalities, and renal impairment. It has previously been reported in 2 families. We describe the clinical phenotype of 8 further individuals from 4 unrelated families with SLC30A9-related disease.
Published research Child disability Kids Rehab Research WAOctober 2023Robust and Interpretable General Movement Assessment Using Fidgety Movement Detection
Fidgety movements occur in infants between the age of 9 to 20 weeks post-term, and their absence are a strong indicator that an infant has cerebral palsy. Prechtl's General Movement Assessment method evaluates whether an infant has fidgety movements, but requires a trained expert to conduct it. Timely evaluation facilitates early interventions, and thus computer-based methods have been developed to aid domain experts.
Cerebral Palsy Published research Child disability Kids Rehab Research WADecember 2023Outcomes following intensive day rehabilitation for young people in Western Australia
Intensive rehabilitation aims to improve and maintain functioning in young people who experience disability due to illness or injury. Day rehabilitation may have advantages for families and healthcare systems over inpatient models of rehabilitation.
Published research Child disability Kids Rehab Research WANovember 2023Profiling the Longitudinal Development of Babbling in Infants with Cerebral Palsy: Validation of the Infant Monitor of Vocal Production (IMP) Using the Stark Assessment of Early Vocal Development-Revised (SAEVD-R)
We compared early vocal development in children "at risk" for cerebral palsy (CP) with typically developing (TD) infants aged 6 to 15 months using the SAEVD-R, investigating potential pre-linguistic markers of communication impairment. Additionally, we sought to examine the agreement between the SAEVD-R and IMP, which uses parent report, in identifying departure from typical vocal development in at-risk infants.
Cerebral Palsy Published research Child disability Kids Rehab Research WAMay 2023Kindy Moves: the feasibility of an intensive interdisciplinary programme on goal and motor outcomes for preschool-aged children with neurodisabilities requiring daily equipment and physical assistance
To determine the feasibility of an intensive interdisciplinary programme in improving goal and motor outcomes for preschool-aged children with non-progressive neurodisabilities. The primary hypothesis was that the intervention would be feasible.
Published research Early Childhood Development Child disability Kids Rehab Research WAMarch 2023ACTIVE STRIDES-CP: Protocol for a randomised trial of intensive rehabilitation (combined intensive gait and cycling training) for children with moderate-to-severe bilateral cerebral palsy
For children with cerebral palsy (CP), who are marginally ambulant, gross motor capacity peaks between 6 and 7 years of age with a subsequent clinical decline, impacting their ability to engage in physical activity. Active Strides-CP is a novel package of physiotherapy targeting body functions, activity and participation outcomes for children with bilateral CP. This study will compare Active Strides-CP to usual care in a multisite randomised waitlist-controlled trial.
Cerebral Palsy Published research Child disability Kids Rehab Research WAMarch 2023Harnessing neuroplasticity to improve motor performance in infants with cerebral palsy: A study protocol for the GAME randomised controlled trial
Cerebral palsy (CP) is the most common physical disability of childhood worldwide. Historically the diagnosis was made between 12 and 24 months, meaning data about effective early interventions to improve motor outcomes are scant. In high-income countries, two in three children will walk. This evaluator-blinded randomised controlled trial will investigate the efficacy of an early and sustained Goals-Activity-Motor Enrichment approach to improve motor and cognitive skills in infants with suspected or confirmed CP.
Cerebral Palsy Published research Child disability Kids Rehab Research WADecember 2022Implementation of an Early Communication Intervention for Young Children with Cerebral Palsy Using Single-Subject Research Design
The implementation of an intervention protocol aimed at increasing vocal complexity in three pre-linguistic children with cerebral palsy (two males, starting age 15 months, and one female, starting age 16 months) was evaluated utilising a repeated ABA case series design. The study progressed until the children were 36 months of age. Weekly probes with trained and untrained items were administered across each of three intervention blocks.
Cerebral Palsy Published research Child disability Kids Rehab Research WANovember 2022From guidelines to practice: A retrospective clinical cohort study investigating implementation of the early detection guidelines for cerebral palsy in a state-wide early intervention service
To report on knowledge translation strategies and outcomes from the implementation of the early detection guidelines for cerebral palsy (CP) in a state-wide tertiary early intervention (EI) service and investigate the impact of social determinants on clinical services.
Cerebral Palsy Published research Child disability Kids Rehab Research WAJuly 2021Clinical utilisation of the Infant Monitor of vocal Production (IMP) for early identification of communication impairment in young infants at-risk of cerebral palsy: a prospective cohort study
Aim: To report prospective longitudinal data of early vocaliszations of infants identified “at-risk” of cerebral palsy (CP) for early identification of communication impairment. This case-control longitudinal prospective cohort study reports on the assessment of 36 infants.
Cerebral Palsy Published research Kids Rehab Research WA -
Education and Qualifications
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Awards/Honours
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Active Collaborations