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        Translational Genomics in Leukaemia

        The Translational Genomics in Leukaemia team is focused on identifying the causes of leukaemia, with the goal of developing new targeted treatments to improve quality of care and long-term survival for all children with leukaemia.

        Despite significant improvements in survival rates over the decades, leukaemia still remains the second cause of cancer-related death in children. Many children with leukaemia continue to have poor prognosis due to treatment-related toxicity, therapy-resistance and relapse, and children with relapsed leukaemia are currently exposed to life-threatening conditions. New treatments are urgently needed to improve long term outcomes for these children. 

        Using cutting-edge technologies and innovative strategies, the main research topics of the Translational Genomics in Leukaemia team are to:

        1. Dissect the genetic molecular causes of leukaemia initiation and development.
        2. Identify the key features of treatment resistance and relapse initiation.
        3. Screen thousands of drugs to eradicate leukaemia cells.
        4. Develop clinically relevant models of leukaemia to assess efficacy of new therapies and facilitate their rapid translational to the clinic.

        Our team collaborates with local, national and international leaders and clinicians to make a tangible difference in improving outcomes for children with leukaemia. .

        Telethon Kids

        Cancer Centre

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        Team

        Leader

        Dr Sébastien Malinge

        PhD

        Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer Council WA Fellow (CCWA), Senior Research Fellow (UWA), University Associate (Curtin)

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        Jesse Armitage
        Postdoctoral Researcher

        Postdoctoral Researcher

        Vivien Nguyen
        Research Assistant

        Research Assistant

        Shannon Carey-Smith
        PhD Student

        PhD Student

        Kunjal Panchal
        PhD Student

        PhD Student

        Kah Ying Wong
        Honours Student

        Honours Student

        Carlos Aya-Bonilla
        Honorary Researcher

        Honorary Researcher

        Related teams

        Translational Genomics in Leukaemia projects

        Development of new preclinical models of childhood leukaemia

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        Exploring clonal diversity in paediatric B-cell leukaemia to identify new therapeutic weakness

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        Other projects

        Reports and Findings

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        June 2024

        The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program

        Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled ETO2 depletion models. We demonstrate that beyond its well-established repressive activity, ETO2 directly activates transcription of MYB, among other genes.

        Children's Cancers Published research Translational Genomics in Leukaemia
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        October 2023

        Down syndrome and leukemia: from basic mechanisms to clinical advances

        Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades.

        Children's Cancers Published research Subsite: Cancer Translational Genomics in Leukaemia Child disability
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        September 2023

        A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors

        Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial.

        Children's Cancers Published research Subsite: Cancer Translational Genomics in Leukaemia Genetics
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        March 2023

        Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response

        A vaccine against influenza is available seasonally but is not 100% effective. A predictor of successful seroconversion in adults is an increase in activated circulating T follicular helper (cTfh) cells after vaccination. However, the impact of repeated annual vaccinations on long-term protection and seasonal vaccine efficacy remains unclear.

        Published research Immunisation Influenza Infectious Diseases Translational Genomics in Leukaemia
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