Wal-yan Respiratory Research Centre
Team
P4 Respiratory Health for Kids projects
Reports and Findings
Exploring the Complexity of the Human Respiratory Virome through an In Silico Analysis of Shotgun Metagenomic Data Retrieved from Public Repositories
Respiratory viruses significantly impact global morbidity and mortality, causing more disease in humans than any other infectious agent. Beyond pathogens, various viruses and bacteria colonize the respiratory tract without causing disease, potentially influencing respiratory diseases’ pathogenesis.
Published research Airway Epithelial Research P4 Respiratory Health for Kids Subsite: Walyan Respiratory viral infectionsThe longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis
In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.
Cystic Fibrosis Published research Early Childhood Development P4 Respiratory Health for Kids Subsite: WalyanTreatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model
Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
Published research Pregnancy and Early Life Immunology Airway Epithelial Research P4 Respiratory Health for Kids Respiratory Environmental Health Bacterial Respiratory Infectious Disease Group Subsite: Walyan BREATHAzithromycin reduces bronchial wall thickening in infants with cystic fibrosis
COMBAT-CF showed that children aged 0-3 years treated with azithromycin did clinically better than placebo but there was no effect on CT-scores. We reanalysed CTs using an automatic bronchus-artery (BA) analysis.
Cystic Fibrosis Published research Early Childhood Development P4 Respiratory Health for Kids Subsite: Walyan