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        Research

        A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis

        The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. ...

        Research

        Alternative Recruitment Strategies Influence Saliva Sample Return Rates in Community-Based Genetic Association Studies

        Using data from three large-scale genetic association studies we compared recruitment strategy and sample return rates. ...

        Research

        Epigenetics in infectious diseases

        Viruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts. ...

        Research

        Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil

        Here we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis... ...

        Research

        Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India

        IL8RA and IL8RB, encoded by CXCR1 and CXCR2, are receptors for interleukin (IL)-8 and other CXC chemokines involved in chemotaxis and activation of... ...

        Research

        Unraveling the genetics of otitis media: From mouse to human and back again

        Otitis media (OM) is among the most common illnesses of early childhood, characterised by the presence of inflammation in the middle ear cavity... ...

        Research

        Host and parasite genomics, an Australasian perspective

        The last decade has seen rapid advances in the genetic technology that is allowing researchers to examine host-pathogen interactions at a whole organism level. ...

        Research

        CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

        To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration.. ...

        Research

        Human genetics of leishmania infections

        GWAS results provide firm confirmation for the importance of antigen presentation and the regulation of IFNγ in determining the outcome of Leishmania infections ...

        Research

        Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil

        Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. ...

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