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        Research

        DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children

        Allergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis. ...

        Research

        Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin

        Dysregulated repair following epithelial injury is a key forerunner of disease in many organs, and the acquisition of a mesenchymal phenotype by the injured... ...

        Research

        Deep inspiration and airway physiology: human, canine, porcine, or bovine?

        Authors: Noble PB, Hernandez JM, Mitchell HW, Janssen LJ. Authors notes: J Appl Physiol. 2010 Aug;109(2):295-304. Keywords: Deep inspiration, airway ...

        Research

        Thoracic Society of Australia and New Zealand position statement: The safe clinical use of sputum induction for bio-sampling of the lower airways in children and adults

        Sputum induction is widely used in clinical settings for collection of biological samples from the lower airways. However, in recent years sputum induction has been associated with serious adverse events and even death. This position statement was commissioned by the Thoracic Society of Australia and New Zealand to address major adverse events of two deaths associated with sputum induction that have occurred in Australia in 2021, and outlines best practice for the safe use of sputum induction.  ...

        Research

        Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease

        Cystic fibrosis (CF) airway disease is characterized by chronic inflammation, featuring neutrophil influx to the lumen. Airway macrophages (AMs) can promote both inflammation and resolution, and are thus critical to maintaining and restoring homeostasis. CF AM functions, specifically scavenging activity and resolution of inflammation, have been shown to be impaired, yet underlying processes remain unknown. ...

        Research

        Genome Sequence of a Lytic Staphylococcus aureus Bacteriophage Isolated from Breast Milk

        We identified a double-stranded DNA (dsDNA) bacteriophage appearing to belong to Herelleviridae, genus Kayvirus. The bacteriophage, Biyabeda-mokiny 1, was isolated from breast milk using a clinical isolate of Staphylococcus aureus. ...

        Research

        Preterm birth: Born too soon for the developing airway epithelium

        This review examines the consequences of preterm birth on the airway epithelium and explores the clinical relevance of currently available models ...

        Research

        Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

        This study found rhinovirus infection drives necrotic cell death in cystic fibrosis airway epithelial cells ...

        Research

        Azithromycin Partially Mitigates Dysregulated Repair of Lung Allograft Small Airway Epithelium

        Chronic airway injury and dysregulated repair programs are evident in airway epithelium obtained from patients with bronchiolitis obliterans syndrome ...

        Research

        Development and validation of a miniaturized bacteriophage host range screening assay against antibiotic resistant Pseudomonas aeruginosa

        Antimicrobial resistance is a current global health crisis, and the increasing emergence of multidrug resistant infections has led to the resurgent interest in bacteriophages as an alternative treatment. ...

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