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        Research

        Junk-food filled neighbourhoods: Building a local evidence-base for change’. Rapid Obesity Policy Translation Program

        Gina Trapp GT BHSc(Hons1A), RPHNutr, PhD ARC DECRA Fellow & Head of Food and Nutrition Research 0410 589 374 Gina.Trapp@telethonkids.org.au ARC ...

        Research

        Reducing the harm caused by radiation for children with brain cancer, including MRI evaluation of impacts of radiation therapy

        Raelene Nick Endersby Gottardo R NG BSc (Hons) PhD MBChB FRACP PhD Brainchild Fellow; Co-Head, Brain Tumour Research Co-Head, Brain Tumour Research ...

        Research

        Monitoring disease progression in childhood bronchiectasis

        Bronchiectasis (not related to cystic fibrosis) is a chronic lung disease caused by a range of etiologies but characterized by abnormal airway dilatation, recurrent respiratory symptoms, impaired quality of life and reduced life expectancy. ...

        Research

        DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

        DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

        Research

        Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

        This JAK3A572V knockin model is a relevant new tool for testing the efficacy of JAK inhibitors in JAK3-related hematopoietic malignancies ...

        News & Events

        Telethon Kids welcomes Future Fund for medical research

        Perth's Telethon Kids Institute has welcomed the passing of legislation to establish the Medical Research Future Fund (MRFF). ...

        Tassie Kids

        A picture of early childhood services in Tasmania from birth to age five ...

        Research

        Undernutrition increases the risk of unsuccessful treatment outcomes of patients with tuberculosis in Ethiopia: A multicenter retrospective cohort study

        While undernutrition has been identified as a common risk factor for tuberculosis (TB), its impact on treatment outcomes has yet to be investigated in high TB burden and low-income countries such as Ethiopia. Therefore, this study aimed to investigate the effect of undernutrition on treatment outcomes among patients with TB in northwest Ethiopia.  ...

        Research

        Risk factors associated with unsuccessful tuberculosis treatment outcomes in Hunan Province, China

        Globally, China has the third highest number of tuberculosis (TB) cases despite high rates (85.6%) of effective treatment coverage. Identifying risk factors associated with unsuccessful treatment outcomes is an important component of maximising the efficacy of TB control programmes. ...

        Research

        The Prevalence of HIV Infection in Minority Indigenous Populations of the South-East Asia and Western Pacific Regions: A Systematic Review and Meta-analysis

        A random effects meta-analysis was used to estimate the pooled prevalence of HIV infection within minority indigenous populations of the South-East Asia (SEAR) and Western Pacific Regions (WPR). Sub-group analyses were conducted, and the sources of heterogeneity explored through meta-regression. The majority of studies were undertaken in high HIV risk subpopulations. ...

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