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        Research

        Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life

        Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. ...

        Research

        Living with lung disease: experimental models to assess the long-term effects of prematurity

        Laboratory models provide an important tool in helping to understand the cellular and molecular drivers of respiratory disease. Many animal models exist that model the neonatal outcomes of preterm birth. ...

        Research

        In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice

        All alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood. ...

        Research

        Early Life Ovalbumin Sensitization and Aerosol Challenge for the Induction of Allergic Airway Inflammation in a BALB/c Murine Model

        This protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age ...

        Research

        Two newly identified cat allergens: The von Ebner gland protein Fel d 7 and the latherin-like protein Fel d 8

        Characterization of the complete IgE binding spectrum of cat allergens is important for the development of improved diagnosis and effective immunotherapeutics. ...

        Research

        Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles

        This study utilized in vitro, in vivo and clinical data to evaluate the palatability of a novel midazolam chocolate tablet. ...

        Research

        Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

        Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways. ...

        Research

        Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infection

        Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection ...

        Research

        Sun exposure and its effects on human health: Mechanisms through which sun exposure could reduce the risk of developing obesity and cardiometabolic dysfunction

        The cardiometabolic protective effects of ultraviolet radiation and mechanistic pathways through which ultraviolet radiation could be beneficial. ...

        Research

        Understanding the aetiology and resolution of chronic otitis media from animal and human studies

        This Clinical Puzzle article describes our current knowledge of chronic otitis media and the existing research models for this condition ...

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