Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2021
• February 2021

Developmental Origins of Health and Disease ...

• The ORIGINS Project
• About ORIGINS

Research Officer ...

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The Critical Role of Parenting in Early Childhood Development In the first few years of life, the family environment is the dominant setting in young ...

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• HPER

Findings from longitudinal research, globally, repeatedly emphasise the importance of a taking an early life course approach to mental health promotion; one that invests in the formative years of development, from early childhood to young adulthood, just prior to the transition to parenthood for most. While population monitoring systems have been developed for this period, they are typically designed for use within discrete stages. ...

• 1. Telethon Kids Institute
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• 2023
• February 2023

Professor Graham Hall suspects he was one of those kids who was always asking, "Why?" As an adult, not much has changed. Except these days, he's ...

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• Professor Graham Hall

This study highlights an unpredicted potential risk factor for the development of food allergy, that is, D pteronyssinus allergens in breast milk ...

• 1. Telethon Kids Institute
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• 2020
• May 2020

The ORIGINS Project has been named as a key beneficiary of the Stan Perron Charitable Foundation Research People & Platform round for 2023. ...

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In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization... ...

• 1. Telethon Kids Institute
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• 2007
• March 2007

There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards "at-risk" infants. The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021