Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

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• 2020
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Systematic comparison of recovered cell types and their transcriptional profiles across the workflows has highlighted protocol-specific biase ...

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• 2020
• June 2020

This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

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• 2019
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Present a valuable resource for drug discovery and have identified ROM as a promising therapeutic for MLL-rearranged iALL ...

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• 2016
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A new research scholarship to combat childhood brain tumours will be launched tonight in honour of two year old Perth toddler Ethan Davies. ...

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André Timo Anthony Kathryn Peter Sam Alex Bep Thomas Schultz Lassmann Kicic Ramsey Richmond Buckberry Brown Uink Iosifidis AS T A KR PC SB AB BU TI ...

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The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. ...

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• 2021
• September 2021

CAGE in combination with single-molecule sequencing technology allows mapping of TSSs and genome-wide capture of promoter activities state cell populations. ...

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• 2017
• September 2017

Epigenetically regulated genes have a great theranostic potential, especially in tumors with no apparent driver mutations. ...

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• 2017
• October 2017

Search our CDKL5 database Our Publications Wong K, Junaid M, Demarest S, Saldaris J, Benke TA, Marsh ED, Downs J and Leonard H. Factors influencing ...

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