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        Early Life Ovalbumin Sensitization and Aerosol Challenge for the Induction of Allergic Airway Inflammation in a BALB/c Murine Model

        This protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age ...

        Research

        Whole-cell pertussis vaccine in early infancy for the prevention of allergy in children

        Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg. ...

        Research

        Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development

        Type 1 and 3 interferon response capacity appears strongly developmentally constrained at birth ...

        Research

        Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

        Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa. ...

        Research

        Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodes

        Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT). ...

        Research

        Th2-polarisation of cellular immune memory to neonatal pertussis vaccination

        Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular... ...

        Research

        Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infection

        Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection ...

        Research

        Prediction of asthma in childhood from wheezing phenotypes up to age 3 years: findings from community cohorts in Western Australian and the United Kingdom

        Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt ...

        Research

        Examining relationships between vitamin D over the first decade of life and development of asthma and allergy

        Pat Prue Holt Hart PG PH PhD, DSc, FRCPath, FRCPI, FAA BSc (Hons) MSc PhD Emeritus Honorary Researcher Head, Inflammation Patrick.Holt@ ...

        Research

        Developmental-associated dysregulation of innate anti-microbial immunity in early life as a determinant of susceptibility to atopic asthma

        Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt ...

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