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        Research

        Understanding group A streptococcal pharyngitis and skin infections as causes of rheumatic fever: Protocol for a prospective disease incidence study

        This study will identify the incidence of true Group A Streptococcal pharyngitis and serological responses to Group A Streptococcal GAS skin infections ...

        Research

        Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

        We identified the existence of more than 290 clinically associated genomic phylogroups across 22 countries, highlighting challenges in designing vaccines of global utility ...

        Research

        Environmental and social determinants of acute rheumatic fever: a longitudinal cohort study

        Prevention strategies in ARF endemic settings may be enhanced by targeting new members entering a community and children in environments of close contact ...

        Research

        Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine

        We propose that hydroxychloroquine could be repurposed to reduce the risk of rheumatic heart disease after acute rheumatic fever ...

        Research

        Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry

        Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells. ...

        Research

        Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess

        We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or MRSA ...

        Research

        Prospective cohort study of childhood behaviour problems and adolescent sexual risk-taking: Gender matters

        This study sought to determine relationships, by gender, between childhood behaviour problems and adolescent risky sexual behaviours and substance use. ...

        Research

        Improving cardiovascular outcomes among Aboriginal Australians: Lessons from research for primary care

        Primary care practitioners have an important role in improving Aboriginal cardiovascular care outcomes ...

        Research

        Epidemiology and mortality of staphylococcus aureus Bacteremia in Australian and New Zealand children

        Describe the epidemiology of Staphylococcus aureus bacteremia in children and adolescents younger than 18 years from Australia and New Zealand ...

        Research

        Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever

        A sample target product profile for reformulated benzathine penicillin G is presented ...

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