The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacte ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• June 2010

Jenefer Timo Carol Sarra Helen Vanessa Blackwell Lassmann Bower Jamieson Leonard Fear JM T C SE HM VF BSc with First Class Honours, PhD, DSc, FMedSci ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Genetics and Health

Sarra Timo Christopher Lea-Ann Ruth Deborah Jamieson Lassmann Blyth Kirkham Thornton Lehmann SE T CC LK RT D BSc (Hons) MSc PhD BSc (Hons) MSc PhD ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Genetics and Health

The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Viruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Uniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

Here we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• March 2015

We believe this data represents a useful resource to understand the central nervous system in macaque. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• March 2017

We found no increased risk of poor development among boys with hypospadias or undescended testis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017