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        An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapies

        Nontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children. ...

        Research

        Re-analysis of the association between perinatal androgens and postnatal head circumference growth

        This paper is a correction of an earlier report that identified a link between exposure to high levels of testosterone during pregnancy and reduced head... ...

        Research

        A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort study

        Pneumococcal surface protein A is immunogenic and natural anti-PspA immune responses are acquired through exposure and develop with age ...

        Research

        Heavy maternal alcohol consumption and cerebral palsy in the offspring

        The aim of this study was to investigate the association between heavy maternal alcohol consumption and pre- peri- and postneonatally acquired cerebral palsy. ...

        Research

        Effect of early carriage of streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy

        The aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the development of T cell responses. ...

        Research

        Dispensing patterns and pregnancy outcomes for women dispensed selective serotonin reuptake inhibitors in pregnancy

        The purpose of this study was to investigate dispensing patterns and pregnancy outcomes for women dispensed an SSRI in pregnancy. ...

        Research

        The use of cross-jurisdictional population data to investigate health indicators of child maltreatment

        To investigate the prevalence, trends, and characteristics of maltreatment and assault related hospital admissions and deaths among children ...

        Research

        ATOMIC Ears: A Phase IIB randomised controlled trial to assess safety, tolerability and acceptability of a 5-day Dornase alfa treatment as an adjunct therapy to ventilation tube insertion for otitis media in children

        Chris Jennifer Lea-Ann Peter Ruth Brennan-Jones Kent Kirkham Richmond Thornton C J LK PC RT PhD RN PhD MBBS MRCP(UK) FRACP PhD Head, Ear Health ...

        The LiLO research team

        Learn about those behind the LiLO research study ...

        Research

        Prevalence and risk factors for parent-reported recurrent otitis media during early childhood

        The objective was to describe the prevalence and risk factors of recurrent otitis media (rOM) in an urban Australian population at 3 years of age. ...

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