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        Research

        Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma

        Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

        Research

        Effectiveness of Palivizumab against Respiratory Syncytial Virus: Cohort and Case Series Analysis

        Palivizumab appeared effective for reducing virologically confirmed respiratory syncytial virus in this high-risk cohort ...

        Research

        Overcoming the challenges of caring for a child with foetal alcohol spectrum disorder: a Pilbara community perspective

        The caregivers in this study have gained valuable knowledge and wisdom through caring for a child with FASD ...

        Research

        Upper Airway Pathology Contributes to Respiratory Symptoms in Children Born Very Preterm

        The upper airway may play a role in the respiratory symptoms experienced by some very preterm children and should be considered by clinicians ...

        Research

        Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial

        Treatment with fluoxetine compared with placebo resulted in significantly lower scores for obsessive-compulsive behaviors at 16 weeks ...

        Research

        Assessing the quality, efficiency and usefulness of the Western Australian population-based Intellectual Disability Exploring Answers (IDEA) surveillance system

        The IDEA system is a valuable resource to address the needs of people living with intellectual disability ...

        Research

        Soy Biodiesel Exhaust is More Toxic than Mineral Diesel Exhaust in Primary Human Airway Epithelial Cells

        Exposure to biodiesel exhaust resulted in significantly greater cell death and a greater release of immune mediators compared to both air controls and ULSD exhaust ...

        Research

        S. aureus colonization in healthy Australian adults receiving an investigational S. aureus 3-antigen vaccine

        Based on descriptive analyses of this small study, S. aureus 3-antigen vaccine vaccination did not impact S. aureus acquisition or carriage ...

        Research

        Measurement of urinary 1-aminopyrene and 1-hydroxypyrene as biomarkers of exposure to diesel particulate matter in gold miners

        The concentrations of 1-AP and 1-OHP increased significantly across a 12-hour mining work shift ...

        Research

        A cross-sectional examination of the clinical significance of autistic traits in individuals experiencing a first episode of psychosis

        Results suggest that autism traits are associated with poorer clinical presentation in first-episode psychosis populations ...

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