The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

This study sought to determine the prevalence of Developmental Language Disorder (DLD) in Australian school-aged children and associated potential risk factors for DLD at 10 years. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

The airway epithelium of children with asthma is characterized by aberrant repair that may be therapeutically modifiable. The development of epithelial-targeting therapeutics that enhance airway repair could provide a novel treatment avenue for childhood asthma. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

In children, chronic wet cough may be a sign of underlying lung disease, including protracted bacterial bronchitis (PBB) and bronchiectasis. Chronic (> 4 weeks in duration) wet cough (without indicators pointing to alternative causes) that responds to antibiotic treatment is diagnostic of PBB. Timely recognition and management of PBB can prevent disease progression to irreversible bronchiectasis with lifelong consequences. However, detection and management require timely health-seeking by carers and effective management by clinicians. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 antagonist and ClpP agonist that has shown preclinical and emerging clinical efficacy in DMG.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Clinicians caring for children and young people with hearing problems should be alert for heightened risk of specific mental health problems based on age and the nature of hearing problems. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

Overlap between non-suicidal self-harm and suicidal ideation and behavior in young people with both symptom continuity and symptom duration implicated in this association ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

This is a protocol for a Cochrane Review (intervention). The objectives were to assess the efficacy and safety of whole‐cell pertussis (wP) vaccinations in comparison to acellular pertussis (aP) vaccinations in early infancy for the prevention of atopic diseases in children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Francis Joel Steve Mitrou Stafford Zubrick FG J SR BEc BA(Hons) MA PhD FASSA, FAAMHS, MSc AM PhD Program Head, Population Health, and Team Head, ...

• Telethon Kids Institute
• Projects
• The ARC Centre of Excellence for Children and Families over the Life Course