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        "Hurts less, lasts longer"; a qualitative study on experiences of young people receiving high-dose subcutaneous injections of benzathine penicillin G to prevent rheumatic heart disease in New Zealand

        Four-weekly intramuscular benzathine penicillin G injections to prevent acute rheumatic fever progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions of BPG which resulted in a much longer effective penicillin exposure, and fewer injections. Here we describe the experiences of young people living with ARF participating in a Phase-II trial of SubCutaneous Injections of BPG. ...

        Research

        Meta-taxonomic analysis of prokaryotic and eukaryotic gut flora in stool samples from visceral leishmaniasis cases and endemic controls in Bihar State India

        We evaluate a meta-taxonomic approach to determine the composition of prokaryotic and eukaryotic gut microflora using sequencing of 16S RNA and 18S rRNA ...

        News & Events

        It’s a draw! Creative study seeks kids’ drawings to help understand sibling dynamics

        Children across Australia aged 4-12 years are being asked to grab their crayons, pencils or pens and create their best drawing of themselves and their siblings in a simple study that will help researchers learn more about sibling relationships. ...

        News & Events

        Sugary drinks in the spotlight

        At the Telethon Institute, many of our studies have uncovered significant health risks associated with both high sugar drinks and energy drinks. ...

        Research

        Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

        Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly... ...

        Research

        TLR1/2 activation during Heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T cell responses providing

        Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species ...

        Research

        Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

        Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically... ...

        Research

        Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in India

        Chromosome 6q26-27 is linked to susceptibility to visceral leishmaniasis (VL) in Brazil and Sudan. ...

        Research

        Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

        Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia,... ...

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