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        Research

        Differences in control by UV radiation of inflammatory airways disease in naïve and allergen pre-sensitised mice

        Exposure of skin to UV radiation (UVR) prior to allergen exposure can inhibit inflammatory airways disease in mice by reducing effector CD4+ T cells in both... ...

        Research

        Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil

        Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. ...

        Research

        Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

        Maintaining sufficient vitamin D is necessary for optimal lung health, and vitamin D may modulate the lung microbiome in a sex-specific fashion ...

        Research

        Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

        Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function ...

        Research

        Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil

        Our results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis ...

        Research

        Polygenic risk of ischemic stroke is associated with cognitive ability

        Findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability ...

        Research

        Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data

        Here we compare the performance of several LMM approaches (and software implementations, including EMMAX, GenABEL, FaST-LMM, Mendel, GEMMA and MMM) via their... ...

        Research

        Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

        We found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. ...

        Research

        Physical Activity-Related Practices and Psychosocial Factors of Childcare Educators: A Latent Profile Analysis

        Limited research investigates early childhood education and care (ECEC) educators' involvement in promoting physical activity. The aim was to identify distinct profiles based on physical activity-related practices and psychosocial factors in ECEC educators and examine how they relate to the amount of time allocated to children's physical activity. A secondary analysis of educator-reported survey data from the Play Active study was undertaken. ...

        Research

        Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers

        The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019.  ...

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