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        Research

        High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease

        Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability, and target exposure profiles of BPG injection are key knowledge gaps for RHD control. ...

        Research

        Converting the maybes: Crucial for a successful COVID-19 vaccination strategy

        Broad community acceptance of a COVID-19 vaccination will be critical for effectively halting the spread of the virus. In this study, we focus on factors that differentiate those who are undecided from those who are either willing or unwilling to accept a prospective COVID-19 vaccine. An online survey in May 2020 assessed Australian adults' willingness to receive a COVID-19 vaccine (yes, maybe, no). A multinomial logistical regression of responses (N = 1,313) was used to identify correlates of vaccine willingness between the three groups. ...

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        Time spent outdoors through childhood and adolescence - assessed by 25-hydroxyvitamin D concentration - and risk of myopia at 20 years

        To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. Participants of the Raine Study Generation 2 cohort had 25(OH)D concentrations measured at the 6-, 14-, 17- and 20-year follow-ups. Participants underwent cycloplegic autorefraction at age 20 years, and myopia was defined as a mean spherical equivalent -0.50 dioptres or more myopic. Logistic regression was used to analyse the association between risk of myopia at age 20 years and age-specific 25(OH)D concentrations. Linear mixed-effects models were used to analyse trajectory of 25(OH)D concentrations from 6 to 20 years. ...

        Research

        The Path to Group A Streptococcus Vaccines: World Health Organization Research and Development Technology Roadmap and Preferred Product Characteristics

        Here, the role, status, and directions in Group A Streptococcus vaccines research are discussed ...

        Research

        Telling an Adult at School about Bullying: Subsequent Victimization and Internalizing Problems

        To prevent persistent victimization, schools and teachers need to be better equipped to respond effectively when a student first becomes a target of bullying ...

        Research

        No detectable effects of acute tryptophan depletion on short-term immune system cytokine levels in healthy adults

        The acute tryptophan depletion condition did not result in significant changes to cytokine concentrations for the entire study sample ...

        Research

        Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

        We identified the existence of more than 290 clinically associated genomic phylogroups across 22 countries, highlighting challenges in designing vaccines of global utility ...

        Research

        Vitamin and mineral supplements: Gut health and probiotics: Probiotics for a healthy microbiome: An evidence-based approach to appropriate product choice

        This review discusses the available evidence base to help provide practical guidance when considering probiotics in practice ...

        Research

        High expression of connective tissue growth factor accelerates dissemination of leukaemia

        Functional role of CTGF in altering disease progression in a lymphoid malignancy ...

        Research

        Addressing the challenges of cross-jurisdictional data linkage between a national clinical quality registry and government-held health data

        Describing the challenges of obtaining state and nationally held data for linkage to a non-government national clinical registry ...

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