In this review, we explore current knowledge and provide guidance as to when and how the inhaled route may be of value when treating patients whose tracheas are intubated ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Apically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

This study assessed an alternative approach, using a small scale halide assay that can be adapted for a personalized high throughput setting to analyze CFTR function of pAEC. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

Antimicrobial resistance is a current global health crisis, and the increasing emergence of multidrug resistant infections has led to the resurgent interest in bacteriophages as an alternative treatment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Severity and disease progression in people with Cystic Fibrosis is typically dependent on their genotype. One potential therapeutic strategy for people with specific mutations is exon skipping with antisense oligonucleotides. CFTR exon 9 is an in-frame exon and hence the exclusion of this exon would excise only 31 amino acids but not alter the reading frame of the remaining mRNA. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

The airway epithelium of both children and adults with asthma is relatively undifferentiated characterized by a significantly increased proportion of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• August 2015

Chronic airway injury and dysregulated repair programs are evident in airway epithelium obtained from patients with bronchiolitis obliterans syndrome ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

This review examines the consequences of preterm birth on the airway epithelium and explores the clinical relevance of currently available models ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

This study found rhinovirus infection drives necrotic cell death in cystic fibrosis airway epithelial cells ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Nontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024