The FANTOM5 cerebellum time series is a high-quality transcriptome database for functional investigation of gene regulatory networks in cerebellar development ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

Rett syndrome is a rare but serious neurological disorder that affects about 1 in 9,000 girls. Even more rarely, boys may be affected. ...

• Rett syndrome and Related Disorders

Effective antitumor CD8 T cell responses may be activated by directly targeting the innate immune system within tumors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2008
• February 2008

T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

RNA-binding proteins and mitochondrial ribosomes have been found to be linchpins of mitochondrial gene expression in health and disease. The expanding repertoire of proteins that bind and regulate the mitochondrial transcriptome has necessitated the development of new tools and methods to examine their molecular functions. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Given that the transcriptional regulatory activity of estrogen receptor (ER) is modulated by its biochemical cofactors, genetic variation within the ER... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• August 2012

We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Article title Colvin, L., Leonard, H., De Klerk, N.,Davis, M., Weaving, L., Williamson, S., & Christodoulou, J. (2004). Refining the phenotype of ...

• Rett syndrome and Related Disorders
• Our Research
• Research snapshots

Article title Bebbington, A, Percy, A, Christodoulou, J, Ravine, D, Ho, G, Jacoby, P, Anderson, A, Pineda, M, Ben Zeev, B, Bahi-Buisson, N, Smeets, E ...

• Rett syndrome and Related Disorders
• Our Research
• Research snapshots

Research has proposed that autistic-like traits in the general population lie on a continuum, with clinical ASD representing the extreme end of this... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• October 2013