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        Research

        IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

        High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

        Research

        Temporally restricted activation of IFNβ signaling determines response to immune checkpoint therapy

        The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

        News & Events

        Four Telethon Kids Institute research leaders named as finalists for West Australian of the Year Awards

        Four outstanding members of the Telethon Kids Institute family have been named as finalists in the 2024 Western Australian of the Year Awards. ...

        News & Events

        Prime Minister visits Telethon Kids

        We welcomed the Prime Minister Malcolm Turnbull, Minister for Finance Mathias Cormann and Minister for Foreign Affairs Julie Bishop to the Institute. ...

        Research

        A Family's Journey at JHC: Analyses of routinely collected data

        Desiree Silva DS MBBS, FRACP, MPH, PhD Co-Head, The ORIGINS Project Co-Head, The ORIGINS Project Professor Desiree Silva is co-director for the ...

        Research

        Electronic Use in Little Ones (EUiLO)

        Mary Brushe MB BPsych(Hons), PhD (Public Health) Senior Research Officer 08 6375 6102 mary.brushe@telethonkids.org.au Senior Research Officer @ ...

        News & Events

        Telethon Kids on the road to Broome again in 2024 thanks to Federal Government grant

        Telethon Kids Institute will bring science to the Kimberley for a second year in 2024 after the Federal Government today announced a $20,000 grant for the Institute to deliver the Broome STEM Festival. ...

        News & Events

        Fellowship paves way for world-first LGBTQA+ suicide prevention initiative

        Dr Penelope Strauss will use a prestigious Post-Doctoral Fellowship from Suicide Prevention Australia to develop and trial a world-first intervention. ...

        Research

        Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study

        In this case-control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the... ...

        Research

        Hospital utilization, costs and mortality rates during the first 5 years of life

        Long-term physical and mental health outcomes of ART singletons are generally reassuring. There is a scarcity of information on health service utilization... ...

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