We propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Blood responses in very preterm infants with LOS are characterised by altered host immune responses that appear to reflect unbalanced immuno-metabolic homeostasis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

The process of referral pathway development provided a service mapping and gapping exercise to facilitate service integration ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

We conclude that updated global recommendations for therapy of nutritional rickets complement previously published position statements for Australia and New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examination of skin scrapings requires sample collection with a sharp scalpel blade, causing discomfort to patients and difficulty in children. Polymerase chain reaction (PCR)-based diagnostic assays, combined with non-invasive sampling methods, represent an attractive approach. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Combination vaccines containing whole-cell pertussis antigens were phased out from the Australian national immunisation programme between 1997 and 1999 and replaced by the less reactogenic acellular pertussis (aP) antigens. In a large case-control study of Australian children born during the transition period, those with allergist diagnosed IgE-mediated food allergy were less likely to have received whole-cell vaccine in early infancy than matched population controls (OR: 0.77 (95% CI, 0.62 to 0.95)). We hypothesise that a single dose of whole-cell vaccine in early infancy is protective against IgE-mediated food allergy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

Benzathine penicillin G (BPG) is used as first-line treatment for most forms of syphilis and as secondary prophylaxis against rheumatic heart disease (RHD). Perceptions that poor quality of BPG is linked to reported adverse effects and therapeutic failure may impact syphilis and RHD control programs. Clinical networks and web-based advertising were used to obtain vials of BPG from a wide range of countries. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

Asha Bowen AC BA MBBS DCH FRACP PhD GAICD OAM Head, Healthy Skin and ARF Prevention Head, Healthy Skin and Arf Prevention Areas of expertise: Skin ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards "at-risk" infants. The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021