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        Research

        Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children

        The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children ...

        Research

        Fetal Alcohol Spectrum Disorder in the Australian Education System: Knowledge, attitudes, needs, and practices

        Amy Carol Roslyn Finlay-Jones Bower Giglia AFJ C RC BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) MBBS MSc PhD FAFPHM DLSHTM FPHA ...

        Research

        Data for policy

        Francis Joel Steve Mitrou Stafford Zubrick FG J SR BEc BA(Hons) MA PhD FASSA, FAAMHS, MSc AM PhD Program Head, Population Health, and Team Head, ...

        Research

        Working Towards a Better Understanding of ARF

        Jonathan Michael Tobias Carapetis AM Serralha Kollmann JR MS TK AM MBBS FRACP FAFPHM PhD FAHMS PhD, M.D., SFUW Executive Director; Head, Strep A ...

        Research

        Normative data for multiple breath washout outcomes in school-aged Caucasian children

        The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. ...

        Research

        Change in health outcomes for First Nations children with chronic wet cough: rationale and study protocol for a multi-centre implementation science study

        In children, chronic wet cough may be a sign of underlying lung disease, including protracted bacterial bronchitis (PBB) and bronchiectasis. Chronic (> 4 weeks in duration) wet cough (without indicators pointing to alternative causes) that responds to antibiotic treatment is diagnostic of PBB. Timely recognition and management of PBB can prevent disease progression to irreversible bronchiectasis with lifelong consequences. However, detection and management require timely health-seeking by carers and effective management by clinicians. ...

        Research

        The prevalence of and potential risk factors for Developmental Language Disorder at 10 years in the Raine Study

        This study sought to determine the prevalence of Developmental Language Disorder (DLD) in Australian school-aged children and associated potential risk factors for DLD at 10 years. ...

        Research

        ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma

        Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 antagonist and ClpP agonist that has shown preclinical and emerging clinical efficacy in DMG.  ...

        Research

        AI-Driven Cell Tracking to Enable High-Throughput Drug Screening Targeting Airway Epithelial Repair for Children with Asthma

        The airway epithelium of children with asthma is characterized by aberrant repair that may be therapeutically modifiable. The development of epithelial-targeting therapeutics that enhance airway repair could provide a novel treatment avenue for childhood asthma. ...

        Research

        Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits

        Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. ...

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