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        Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

        Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem. ...

        Research

        Fecal sample collection methods and time of day impact microbiome composition and short chain fatty acid concentrations

        Associations between the human gut microbiome and health outcomes continues to be of great interest, although fecal sample collection methods which impact microbiome studies are sometimes neglected. Here, we expand on previous work in sample optimization, to promote high quality microbiome data. To compare fecal sample collection methods, amplicons from the bacterial 16S rRNA gene (V4) and fungal (ITS2) region, as well as short chain fatty acid (SCFA) concentrations were determined in fecal material over three timepoints. ...

        Brain development

        Interview Evidence Report Research Snapshot ChatterBox game About the game News Article with Rosemarie Perry Building Strong Foundations for Healthy ...

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        Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: A randomized controlled trial

        Increased maternal egg ingestion is associated with increased breastmilk ovalbumin, and markers of immune tolerance in infants ...

        Research

        Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth

        IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.  ...

        Research

        Longitudinal egg-specific regulatory T- and B-cell development: Insights from primary prevention clinical trials examining the timing of egg introduction

        Egg allergy affects almost 1 in 10 Australian infants. Early egg introduction has been associated with a reduced risk in developing egg allergy; however, the immune mechanisms underlying this protection remain unclear. ...

        Research

        Prebiotics: mechanisms and preventive effects in allergy

        In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention ...

        People

        Lieke van den Elsen

        Honorary Postdoctoral Researcher ...

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        Research

        In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice

        In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in... ...

        Research

        Ovalbumin in breast milk is associated with a decreased risk of IgE-mediated egg allergy in children

        Showed for the first time that the presence of an egg-derived allergen in breast milk is associated with a reduced risk of egg allergy in children at 2.5 years of age ...

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