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        Research

        IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

        High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

        Research

        Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis

        The aim of our study was to characterize the activity of TNAP on TLR agonists and assess the concentrations of plasma ALP during late-onset sepsis in newborns. ...

        Research

        Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

        We aimed to measure the antibody development to 2 bacteria in a birth cohort at high risk of allergic disease, and to assess which responses are asthma-linked. ...

        Research

        Effects of Ser47-Point Mutation on Conformation Structure and Allergenicity of the Allergen of Der p 2, a Major House Dust Mite Allergen

        The mutant Der p 2 had altered structure and reduced ability to stimulate pro-inflammatory responses and to bind IgE ...

        Research

        Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthma

        Bacterial colonisation of the airways is associated with increased risk of childhood asthma ...

        Research

        Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

        Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life ...

        News & Events

        Ependymoma Awareness Day

        Ethan was not even two when he was diagnosed with a rare type of brain tumour known as an ependymoma. ...

        Research

        Immune cell trafficking from the brain maintains CNS immune tolerance

        Evaluation of fluorescently labeled leukocyte migration in mice revealed that DCs travel via the RMS from the CNS to the cervical LNs (CxLNs), where they... ...

        Research

        Integrated analysis of miRNA and mRNA expression in childhood Medulloblastoma

        Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity. ...

        Research

        International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma

        This multi-center study provides valuable information on the success rate of establishing patient-derived pre-clinical models of diffuse intrinsic pontine glioma ...

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