Malignant central nervous system (CNS) cancers are among the most difficult to treat, with low rates of survival and a high likelihood of recurrence. This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

UVR or sunlight exposure may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

Terrance W. Joost Ben Johns Lesterhuis Wylie T WJL BW BSc PhD Honorary Research Associate Program Head, Cancer; Chronic and Severe Diseases RFA ...

• 1. Telethon Kids Institute
• Projects

Our popular workshops for kids are back these school holidays and we have a jam-packed program full of fun and engaging science activities! ...

• Discovery Centre
• News & Events
• 2021
• September

Whole genome sequencing of poor and exceptional survivors identified a gain in Chromosome 19 that was exclusive to the exceptional survivors ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Engaging activities to help families keep kids happy and healthy during social isolation are available in an Australian app underpinned by the latest child development science. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2020
• April

The realisation of human potential for development requires age-specific investment throughout the 8000 days of childhood and adolescence. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

Bacillus cereus can cause serious infections in immunosuppressed patients. This population may be susceptible to B. cereus pneumonia, bacteremia, cellulitis,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• April 2013