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        Research

        Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

        The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations. ...

        Research

        Integrated Analysis of miRNA and mRNA Expression in Childhood Medulloblastoma Compared with Neural Stem Cells

        Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity. ...

        Research

        Using causal directed acyclic graphs (DAGs) to select patient-important outcomes in transplantation trials—interventions to treat polyomavirus infection as an example

        Tom Snelling T BMBS DTMH GDipClinEpid PhD FRACP Head, Infectious Disease Implementation Research 08 6319 1817 tom.snelling@telethonkids.org.au Head, ...

        Research

        Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

        We report on 3 children treated with vismodegib who developed widespread growth plate fusions that persist long after cessation of therapy. ...

        Research

        Lurasidone for Adolescents With Complex Mental Disorders: A Case Series

        Lurasidone is a new second generation (atypical) antipsychotic agent with unique receptor affinity and side-effect profiles, but limited literature is available on its use in adolescent populations. Contrasting with research treatment trials which typically recruit patients by stringent selection criteria, this case series examined the effects and tolerability of using lurasidone in adolescents within real-life clinical settings in treating complex cases who had not responded to other therapy options. We conducted a retrospective case-note audit of 6 adolescents aged 14 to 17 years old attending community child and adolescent mental health services (CAMHS) who were prescribed lurasidone. ...

        Research

        Toll-like receptor 2 ligands inhibit Th2 responses to mite allergen

        There is intense interest in the interaction between microbial compounds and allergy. ...

        Research

        Protective Vaccine Responses in Infants after Maternal Pertussis Vaccination (PRIME) Study

        Christopher Jennifer Peter Blyth Kent Richmond CC J PC MBBS (Hons) DCH FRACP FRCPA PhD RN MBBS MRCP(UK) FRACP Director, Wesfarmers Centre of Vaccines ...

        Perseverance pays off for critically ill patients

        A legal change fought for by Telethon Kids, senior clinicians, consumer advocates, and others within the health sector – and hastened by the COVID-19 ...

        Research

        Precision-guided treatment in high-risk pediatric cancers

        Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear which patients will benefit most from precision-guided treatment. ...

        Research

        Efficacy of acute myeloid leukemia therapy without stem-cell transplantation in a child with blastic plasmacytoid dendritic cell neoplasm

        Our case demonstrates that AML therapy, without HSCT, can be sufficient to treat this rare disease in children. ...

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