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        Research

        Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches

        Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation ...

        Research

        Transcription factor p63 regulates key genes and wound repair in human airway epithelial Basal cells

        The airway epithelium in asthma displays altered repair and incomplete barrier formation. ...

        Research

        Multi-modality monitoring of cystic fibrosis lung disease: the role of chest computed tomography

        Stratification of monitoring protocols based on the risk profile of the patient can help us in the future to better care for people with Cystic Fibrosis. ...

        Research

        Productive infection of human embryonic stem cell-derived nkx2.1+ respiratory progenitors with human rhinovirus.

        Our experiments provide proof of principle for the use of PSC-derived respiratory epithelial cells in the study of cell-virus interactions. ...

        Research

        Early pulmonary inflammation and lung damage in children with cystic fibrosis

        Airway inflammation and infection are present from early in life, often before children are symptomatic. ...

        Research

        Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

        HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

        Research

        The genetic and epigenetic landscapes of the epithelium in asthma

        Genetic factors in airway epithelial cells that are functionally associated with asthma pathogenesis ...

        Research

        Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity

        In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. ...

        Research

        Dissecting the regulation of bile-induced biofilm formation in staphylococcus aureus

        Wall teichoic acid may be important for protecting S. aureus against exposure to bile ...

        Research

        Bile signalling promotes chronic respiratory infections and antibiotic tolerance

        Bile acid signalling is a leading trigger for the development of chronic phenotypes underlying the pathophysiology of chronic respiratory disease ...

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