In-solution hybridisation enrichment of genetic variation is a valuable methodology in human paleogenomics. It allows enrichment of endogenous DNA by targeting genetic markers that are comparable between sequencing libraries. Many studies have used the 1240k reagent-which enriches 1,237,207 genome-wide SNPs-since 2015, though access was restricted. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

To examine and synthesise recent evidence on the role of grandparents in shaping children's dietary health. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Undernutrition is a major risk factor for tuberculosis (TB), which is estimated to be responsible for 1.9 million TB cases per year globally. The effectiveness of micronutrient supplementation on TB treatment outcomes and its prognostic markers (sputum conversion, serum zinc, retinol and haemoglobin levels) has been poorly understood. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Previous studies have reported an association between low birthweight and elevated blood pressure (BP) in adulthood, but few have examined the relationship between foetal growth and adult BP. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

While UV radiation is a skin carcinogen, this should not obscure the growing evidence that sunlight has significant health benefits, including impacts on cardiovascular and metabolic health. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

As malaria incidence decreases and more countries move towards elimination, maps of malaria risk in low-prevalence areas are increasingly needed. For low-burden areas, disaggregation regression models have been developed to estimate risk at high spatial resolution from routine surveillance reports aggregated by administrative unit polygons. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

The aim of this study was to provide a comprehensive evidence on risk factors for transmission, disease severity and COVID-19 related deaths in Africa. A systematic review has been conducted to synthesise existing evidence on risk factors affecting COVID-19 outcomes across Africa. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Limited evidence is available regarding dentists' knowledge and interpretation of infective endocarditis (IE) prophylaxis guidelines. The aim of this study was to determine understanding and management of rheumatic and non-rheumatic valvular heart disease (VHD) in the dental setting in Western Australia (WA). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

While access to highly active antiretroviral therapy (HAART) for children with HIV has expanded and the use of HAART has substantially reduced the morbidity and mortality of children due to HIV, poor treatment outcomes among children with HIV are still a major public health problem globally. The aim of this systematic review and meta-analysis is to quantify treatment outcomes among children with HIV. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

Multidrug-resistant tuberculosis (MDR-TB) is a major global public health concern. However, there is a dearth of literature on whether MDR-TB and its medications impact maternal and perinatal outcomes, and when such evidence exists the findings are conflicting. This systematic review and meta-analysis aimed to examine the impact of MDR-TB and its medications during pregnancy on maternal and perinatal outcomes. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020