Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children during acute virus-associated exacerbations and later during convalescence. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Human perinatal life is characterized by a period of extraordinary change during which newborns encounter abundant environmental stimuli and exposure to potential pathogens. To meet such challenges, the neonatal immune system is equipped with unique functional characteristics that adapt to changing conditions as development progresses across the early years of life, but the molecular characteristics of such adaptations remain poorly understood. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric acute respiratory infection (ARI). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

Australia’s Childhood Immunisation Register (ACIR) is one of only a handful of national immunisation registers world-wide. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Findings are the first linking atopy (measured by both parent report and objective verification) with increased vulnerability to affective and anxiety problems ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

We sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, contribute to asthma inception. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

The epidemic increase in the prevalence of allergic disease, which first started in the industrialized countries in the 1960s, may have reached a peak in the... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

Eczema often precedes the development of asthma in a disease course called the 'atopic march'. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Although debate surrounding the mechanism or mechanisms governing this causal pathway remains intense, demonstration of the capacity of pretreatment... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• May 2015

We conducted an open randomized controlled trial in Papua New Guinea to compare safety, immunogenicity and priming for memory of 7-valent PCV (PCV7) given in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013