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        Research

        Route of exposure alters inflammation and lung function responses to diesel exhaust

        In this study, we compared the physiological consequences of short-term exposure to diesel exhaust via inhalation to those due to exposure to the same diesel... ...

        News & Events

        Lung study helps history-making generation get a handle on their health

        A lung function study carried out by Dr Shannon Simpson provided the most comprehensive follow-up of very pre-term children of any study so far carried out on the lung health of this vulnerable group. ...

        Research

        Children’s regenerative and genetic medicine program

        André Anthony Stephen Schultz Kicic Stick AS A SM MBChB, PhD, FRACP BSc (Hons) PhD MB BChir PhD MRCP FRACP Program Head, Respiratory Health RFA ...

        Research

        COCOON: Virus transmission, immunity, and family wellbeing during COVID-19

        Asha Desiree Stephen Susan Bowen Silva Stick Prescott AC DS SM SL BA MBBS DCH FRACP PhD GAICD MBBS, FRACP, MPH, PhD MB BChir PhD MRCP FRACP MBBS ...

        Research

        Compound Repurposing Into Novel Therapeutics In COVID-19 At risk Lungs (CRITICAL Study)

        Anthony Christopher David Ingrid Shannon Thomas Kicic Blyth Martino Laing Simpson Iosifidis A CC DM IL SS TI BSc (Hons) PhD MBBS (Hons) DCH FRACP ...

        Research

        Epithelial Drivers of Neutrophil Plasticity in Early Cystic Fibrosis Lung Disease

        Anthony Stephen Kicic Stick A SM BSc (Hons) PhD MB BChir PhD MRCP FRACP Rothwell Family Fellow; Head, Airway Epithelial Research Head, P4 Respiratory ...

        Research

        WA Epithelial Research Program for Childhood Respiratory Diseases

        Anthony Stephen Kicic Stick A SM BSc (Hons) PhD MB BChir PhD MRCP FRACP Rothwell Family Fellow; Head, Airway Epithelial Research Head, P4 Respiratory ...

        Research

        Respiratory Health Program

        Listed are the Telethon Kids Institute research teams involved in our Respiratory Health Program. This program sits under the Chronic and Severe Diseases research theme. ...

        Research

        An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapies

        Nontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children. ...

        Research

        Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiella pneumoniae infections

        Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam or ceftazidime-avibactam in vitro and in vivo against diverse CPKp clinical isolates. ...

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