Cardiovascular disease occurs prematurely in type 1 diabetes. The additional risk of overweight is not well characterized. The primary aim was to measure the impact of body mass index (BMI) in youth with type 1 diabetes on cardiovascular risk factors. The secondary aim was to identify other determinants of cardiovascular risk. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

To investigate glycemic and psychosocial outcomes with hybrid closed-loop (HCL) versus user-determined insulin dosing with multiple daily injections (MDI) or insulin pump (i.e., standard therapy for most adults with type 1 diabetes). Adults with type 1 diabetes using MDI or insulin pump without continuous glucose monitoring (CGM) were randomized to 26 weeks of HCL (Medtronic 670G) or continuation of current therapy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial and observational cohort study, we characterized the progression of vascular phenotypes throughout this important period and investigated the effect of ACE (angiotensin-converting enzyme) inhibitors and statins in high-risk adolescents. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

Adolescents with polycystic ovary syndrome (PCOS) have increased incidence of cardiometabolic risk factors including dyslipidemia. Atherogenic apolipoprotein (apo) B-lipoprotein remnants are associated with increased cardiovascular disease (CVD) risk. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

We report an overall good adherence to ACE inhibitors and statins during a clinical trial, although there was a clear decline in adherence over time ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Wearable technologies impact upon sexual activity and this influences the decision to adopt the technology ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

This multinational study presents unique body mass index z score trajectories in youth with type 1 diabetes across three continents ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Improved frequency of sensor use improves glycaemic control ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

These findings present an opportunity to move towards the personalized care of adolescents with type 1 diabetes mellitus ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

A high-protein meal requires ~50% more insulin to maintain euglycaemia than a low-protein meal that contains the same quantity of carbohydrate ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019