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        Research

        Ontogeny of toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants

        Studies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in... ...

        Research

        Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

        The aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with persisting wheeze and asthma. ...

        Research

        Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial

        We conducted an open randomized controlled trial in Papua New Guinea to compare safety, immunogenicity and priming for memory of 7-valent PCV (PCV7) given in... ...

        Research

        Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery

        The authors previously reported an increased risk of hospitalisation for acute lower respiratory infection up to age 2 years in children delivered by... ...

        Research

        Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood

        The effect of breast-feeding on the development of allergic disease is uncertain ...

        Research

        Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

        The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. ...

        Research

        Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthma

        Bacterial colonisation of the airways is associated with increased risk of childhood asthma ...

        Research

        Evaluation of impact of 23 valent pneumococcal polysaccharide vaccine following 7 valent pneumococcal conjugate vaccine in Australian Indigenous children.

        Deborah Lehmann D AO, MBBS, MSc Honorary Emeritus Fellow Honorary Emeritus Fellow Authors: Jayasinghe S, Chiu C, Menzies R, Lehmann D, Cook H, Giele ...

        Research

        Dahlem Conference

        There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. ...

        Research

        Toll-like receptor 7 function is reduced in adolescents with asthma

        Anti-viral innate immune responses may be impaired in asthma, although the mechanisms are not well understood. ...

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