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        Research

        The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and Disease

        Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORIGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections. ...

        Research

        Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS + Circulating T-Cells

        Our findings suggest that utilization of IL-7 by cTFH cells affects production of IgG2 antibodies to PPV23 antigens in some HIV patients ...

        Research

        Rule-based exposure assessment versus case-by-case expert assessment using the same information in a community-based study

        Expert assessment is often used to assess lifetime occupational exposures, but these assessments generally lack transparency and are very time-consuming. ...

        Research

        Lives on hold: A qualitative synthesis exploring the experience of chronic low-back pain

        Chronic nonspecific low-back pain (CLBP) is a prevalent, costly condition that is remarkably resistant to intervention. ...

        Research

        Clinical Predictors of Influenza in Young Children: The Limitations of “Influenza-Like Illness”

        This study aims to identify clinical predictors of influenza infection in children ≤5 years old from which age-specific ILI definitions are then constructed. ...

        Research

        A Retrospective case-series of children with bone and joint infection from northern Australia

        We report osteomyelitis incidence in indigenous children of northern Australia is amongst the highest reported in the world ...

        Research

        Benzathine penicillin G for the management of RHD: Concerns about quality and access, and opportunities for intervention and improvement

        Benzathine penicillin G is an important antibiotic for the treatment and prevention of group A streptococcal infections associated with rheumatic fever and... ...

        Research

        Patterns trends and increasing disparities in mortality for Aboriginal and non-Aboriginal infants born in Western Australia 1980-2001: population database study

        Since there are known disparities between Aboriginal and non-Aboriginal populations in Australia, trends in infant mortality rates can be used to assess the... ...

        Research

        Hypoglycaemia, fear of hypoglycaemia and quality of life in children with Type 1 diabetes and their parents

        To evaluate the association between fear of hypoglycaemia, episodes of hypoglycaemia and quality of life in children with Type 1 diabetes and their parents. ...

        Research

        Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia

        Sensor-augmented insulin pump with automated low-glucose insulin suspension has the potential to reduce the incidence of major hypoglycemic events. ...

        Research

        Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

        No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence... ...

        Research

        Trends in sugar supply and consumption in Australia: is there an Australian Paradox?

        High consumption of refined carbohydrate, in particular sugar, has been identified as a possible contributory factor in greater risk of excess weight gain. ...

        Research

        Diet in the early years of life influences cognitive outcomes at 10 years: A prospective cohort study

        The aim of this study was to investigate the association between diet during the first 3 years of life and cognitive outcomes at 10 years of age. ...

        News & Events

        WA Cohorts Network welcomes FHRI Funding Announcement

        The State Government has launched the new WA Cohort Studies Research Project Support Program, recognising the value and importance of the three major cohort studies in WA. ...

        Helping communities take charge of the early years

        Did you know? One in five children in WA is considered vulnerable on one or more developmental domains by the age of five. Vulnerability through ...

        Research

        Living liveable? RESIDE's evaluation of the “Liveable Neighborhoods” planning policy on the health supportive behaviors and wellbeing of residents in Perth

        New suburban communities built in accordance with the “Liveable Neighbourhoods” policy have the potential to encourage health supportive behaviors ...

        Research

        Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region

        The major burden of disease is in developing and tropical settings where topical antibiotics are impractical and lead to rapid emergence of antimicrobial... ...

        Research

        CASSETTE-clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: Study protocol for a randomised controlled trial

        This study will assess the effect of adjunctive clindamycin on patient-centred outcomes in severe, toxin-mediated S. aureus infections ...

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