Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV1, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

Institute Director; Head, Strep A Translation; Co-Founder of REACH ...

• 1. Telethon Kids Institute
• Contact us
• Our people
• Staff Profiles - C

The stillbirth rate among Aboriginal and Torres Strait Islander women and communities in Australia is around double that of non-Indigenous women. While the development of effective prevention strategies during pregnancy and improving care following stillbirth for women and families in communities has become a national priority, there has been limited progress in stillbirth disparities. With community permission, this study aimed to gain a better understanding of community experiences, perceptions, and priorities around stillbirth. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

Promotion of periconceptional folic acid supplement use began in Australia following publication of randomised trials showing effectiveness. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

This review supports the recommended use of palivizumab for reducing RSV-associated hospitalisation rates in premature babies born at gestational age <33 weeks. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

House dust mites (HDM) are a globally important source of allergen responsible for the sensitization of more than 50% of allergic patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

The objective of this paper is to determine how well the EDI predicts a child's later literacy and numeracy outcomes as assessed by the National Assessment... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• April 2013

With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemotherapy is widely used in combination with immune checkpoint blockade (ICB). Although a variety of isolated immunostimulatory effects have been reported for several classes of chemotherapeutics, it is unclear which chemotherapeutics provide the most benefit when combined with ICB. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

There is a paucity of quantitative measures of resilience specifically validated for young Aboriginal people in Australia. We undertook the first investigation of validity and reliability of the Connor-Davidson Resilience Scale in a sample of Australian Aboriginal people, with a focus on youth. We conducted a cross-sectional study of resilience among a sample of 122 Aboriginal youth (15–25 years old) in New South Wales and Western Australia, featuring self-completes of the 10-item CD-RISC in online (N = 22) and face-to-face (N = 100) settings. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021