Review of the clinical and biological progress over 50 years in Rett Syndrome ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

Acute tryptophan depletion, and therefore, diminished substrate availability for brain 5-HT synthesis did not lead to significant changes in serum neuropeptide Y concentrations over time ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

Hayley Liz Steve Christian Wenden Zubrick HC LW SR BSc (1st Class Hons), PhD W.Aust. BHlthSc MPH FASSA, FAAMHS, MSc AM PhD Program Head, Healthy ...

• Telethon Kids Institute
• Projects

Hand function is particularly affected and we discuss theoretical and practical perspectives for optimising hand function in Rett syndrome. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the disease and the impact of current therapies are limited. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

The Pregnancy and Early Life Immunology team's overall research vision is targeted towards understanding immunological development during early life. ...

• Telethon Kids Institute
• Our research
• Early Environment
• Immunobiology & Immunotherapeutic Program

We found that BCG, in a mouse model of neonatal polymicrobial sepsis, induced granulocyte colony-stimulating factor (G-CSF) within hours of administration ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Vaccination remains one of the most effective means of reducing the burden of infectious diseases globally. Improving our understanding of the molecular basis for effective vaccine response is of paramount importance if we are to ensure the success of future vaccine development efforts. We applied cutting edge multi-omics approaches to extensively characterize temporal molecular responses following vaccination with hepatitis B virus (HBV) vaccine. Data were integrated across cellular, epigenomic, transcriptomic, proteomic, and fecal microbiome profiles, and correlated to final HBV antibody titres. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

At the nexus of human immunology and microbiology, we investigate the impact of early-life microbiome in priming the immune system, especially the immune memory, for long-term health outcomes. ...

• Telethon Kids Institute
• Our research
• Early Environment
• Immunobiology & Immunotherapeutic Program

We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020