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        Research

        Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

        Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; however, mechanistic and functional validation of these mutations is lacking. ...

        Research

        Intake of polyphenols from cereal foods and colorectal cancer risk in the Melbourne Collaborative Cohort Study

        Cereal-derived polyphenols have demonstrated protective mechanisms in colorectal cancer (CRC) models; however, confirmation in human studies is lacking. Therefore, this study examined the association between cereal polyphenol intakes and CRC risk in the Melbourne Collaborative Cohort Study (MCCS), a prospective cohort study in Melbourne, Australia that recruited participants between 1990 and 1994 to investigate diet-disease relationships. ...

        Research

        Lessons learnt from influenza vaccination in immunocompromised children undergoing treatment for cancer

        Influenza infection contributes substantially to global morbidity and mortality, with children undergoing treatment for cancer among the most vulnerable due to immunosuppression associated with disease and treatment. However, influenza remains one of the most common vaccine-preventable diseases. ...

        News & Events

        Associate Professor Nick Gottardo awarded Cure Brain Cancer Foundation Innovation Grant 2017

        Telethon Kids cancer researcher & clinician Dr Nick Gottardo has been announced as the recipient of an Innovation Grant from the Cure Brain Cancer Foundation. ...

        Unlocking the mysteries of the immune system to tackle childhood cancer

        Dr Joost Lesterhuis and his colleagues in the Sarcoma Translational Research Team are working on an immunotherapy gel that could be applied directly ...

        Research

        Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discovery

        This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

        Research

        The role and therapeutic implications of T cells in cancer of the lung

        This review examines the role of T cells in lung cancer, discussing the direction and clinical significance of current and future immunotherapeutic strategies ...

        Research

        Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects

        The presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer ...

        Research

        A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence

        Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects. ...

        Research

        Adherence to Oral Targeted Anti-Lung Cancer Therapy: A Qualitative Interview Study

        Oral targeted antineoplastic drugs (OTADs) are becoming more and more acceptable for lung cancer treatment due to their advantages such as the convenience of administration and milder side effects. However, medication adherence represents a major issue for prolonged OTAD treatment. ...

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