The Opportunity The Wesfarmers Centre of Vaccines & Infectious Diseases brings together a number of independent researchers and teams with a common ...

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DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

• 1. Telethon Kids Institute
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• 2021
• January 2021

Desiree Susan Professor Catherine Jane Silva Prescott Elliott Valentine DS SL CE JV MBBS, FRACP, MPH, PhD MBBS BMedSci PhD FRACP PhD, BSc (OT) MBBs ...

• 1. Telethon Kids Institute
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Group A β-haemolytic Streptococcus (GAS), a Gram-positive bacterium, causes skin, mucosal and systemic infections. Repeated GAS infections can lead to autoimmune diseases acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Aboriginal and Torres Strait Islander peoples in Australia have the highest rates of ARF and RHD in the world. ...

• 1. Telethon Kids Institute
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• 2022
• March 2022

An international team of researchers has pioneered a technique which gives unprecedented insight into the dramatic changes occurring in a baby’s body in the first week of life. ...

• 1. Telethon Kids Institute
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• 2019
• March

Occupational therapy research has not fully utilized available research methods when exploring occupational therapists' views on specific interventions and service provision nor when exploring consumer priorities and the impact of occupational therapy services. Q methodology, a quantitative method for the systematic assessment of qualitative data, is an approach that can be used to examine viewpoints related to occupational therapy. ...

• 1. Telethon Kids Institute
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• 2021
• May 2021

  Amber Mum of four, Ethany, Xavier, Imogen and Adison. Co-founder of Tiny Sparks WA, Chair of Preterm Community Reference Group, Wal-yan Respiratory ...

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Adolescent girls appear more vulnerable to experiencing mental health difficulties from social media use than boys. The presence of sexualized images online is thought to contribute, through increasing body dissatisfaction among adolescent girls. ...

• 1. Telethon Kids Institute
• Our research
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• 2022
• June 2022

Maternal immunization with pneumococcal conjugate vaccine (PCV) may protect young infants in high-risk settings against the high risk of pneumococcal infections in early life. The aim of this study was to determine the safety and immunogenicity of 13-valent PCV (PCV13) in healthy women of childbearing age in PNG. ...

• 1. Telethon Kids Institute
• Our research
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• 2020
• November 2020

Our data emphasize the heterogeneity of NMC and highlights genetic aberrations that could be explored to improve therapeutic strategies. ...

• 1. Telethon Kids Institute
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• 2017
• December 2017