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        Research

        2023 Australian guideline for assessing and managing cardiovascular disease risk

        The 2023 Australian guideline for assessing and managing cardiovascular disease risk provides updated evidence-based recommendations for the clinical assessment and management of cardiovascular disease (CVD) risk for primary prevention. It includes the new Australian CVD risk calculator based on an equation developed from a large New Zealand cohort study, customised and recalibrated for the Australian population. The new guideline replaces the 2012 guideline that recommended CVD risk assessment using the Framingham risk equation.  ...

        Research

        Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015

        Globally, life expectancy from birth increased from 61·7 years in 1980 to 71·8 years in 2015 ...

        Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

        Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus Discover. Prevent. Cure. ...

        Research

        Fine motor skills in a population of children in remote Australia with high levels of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder

        we aim to create a profile of fine motor skills in a cohort of WA children; determine whether these differed in children with PAE or FASD and prevalence. ...

        Research

        Early vocabulary development: The importance of joint attention and parent-child book reading

        The current study brought a bioecological approach to children’s early vocabulary development using data from the Longitudinal Study of Australian Children... ...

        Research

        Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in

        There is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced malignant pleural mesothelioma. ...

        Research

        FeBRILe3: Safety Evaluation of Febrile Infant Guidelines Through Prospective Bayesian Monitoring

        Despite evidence supporting earlier discharge of well-appearing febrile infants at low risk of serious bacterial infection (SBI), admissions for ≥48 hours remain common. Prospective safety monitoring may support broader guideline implementation. ...

        Research

        Longitudinal impact of the Cyber Friendly Schools program on adolescents' cyberbullying behavior

        Cyber Friendly Schools program was associated with significantly greater declines in the odds of involvement in cyber-victimization and perpetration ...

        Research

        Respiratory syncytial virus is present in the neonatal intensive care unit

        The results suggest that though the risk for RSV in the NICU remains low, personnel clothing are contaminated with RSV-RNA and may have a role in transmission ...

        Research

        Drug-gene modeling in pediatric T-cell acute lymphoblastic leukemia highlights importance of 6-mercaptopurine for outcome

        This study advances our understanding of drug resistance in T-ALL and provides new markers for patient stratification. ...

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