Myeloperoxidase is released by neutrophils in inflamed tissues. MPO oxidizes chloride, bromide, and thiocyanate to produce hypochlorous acid, hypobromous acid, and hypothiocyanous acid, respectively. These oxidants are toxic to pathogens, but may also react with host cells to elicit biological activity and potential toxicity. In cystic fibrosis and related diseases, increased neutrophil inflammation leads to increased airway MPO and airway epithelial cell exposure to its oxidants. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Meet our survey team and our survey reference group ...

• Young Minds Matter

To conduct a systematic review of the evidence for the management of tone in infants 0-24 months of age, with or at risk of developing cerebral palsy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Elevated egg-specific Th2 cytokine responses were established prior to egg ingestion at 4months and were not significantly altered by introduction of egg ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

This natural experiment investigated the influence of early childhood education and care outdoor physical environment upgrade on preschoolers' physical activity ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

We compared early vocal development in children "at risk" for cerebral palsy (CP) with typically developing (TD) infants aged 6 to 15 months using the SAEVD-R, investigating potential pre-linguistic markers of communication impairment. Additionally, we sought to examine the agreement between the SAEVD-R and IMP, which uses parent report, in identifying departure from typical vocal development in at-risk infants. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

New Study ‘Plugs’ Digital Intervention for Perinatal Mental Health ...

• The ORIGINS Project
• News

In this cohort, as compared with the AREST CF cohort, the authors highlight the limited correlation between infection and inflammation with lung function and structural impairment, and that this was mainly explained by the mild changes identified in lung function and on chest CT scan. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

Little is known about how sun exposure may affect the maternal skin barrier during pregnancy when many hormonal and physiological changes occur. In this longitudinal observational study, 50 pregnant women were recruited at 18-24 weeks' gestation, 25 in summer-autumn, and 25 in winter-spring. At three time points in pregnancy at 18-24, 28-30, and 36-38 weeks' gestation, participants completed a validated sun exposure questionnaire and had skin permeability and surface pH measured on the volar forearm. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

Childhood maltreatment and history of parental SSD are associated independently with poor early childhood social-emotional functioning ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• August 2016