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        Research

        Introducing the ORIGINS project: a community-based interventional birth cohort

        Non-communicable diseases (NCDs) pose the greatest threat to human health globally. The dramatic rise in early onset NCDs - such as childhood obesity, the allergy epidemic and an increasing burden of mental ill health in children and youth - reflect the profound early impact of modern environments on developing systems. ...

        Research

        Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response

        Epidemiological studies have demonstrated that survivors of acute burn trauma are at long-term increased risk of developing a range of morbidities. The mechanisms underlying this increased risk remain unknown. This study aimed to determine whether burn injury leads to sustained immune dysfunction that may underpin long-term morbidity. Plasma and peripheral blood mononuclear cells were collected from 36 pediatric burn survivors >3 years after a non-severe burn injury (<10% total body surface area) and from age/sex-matched non-injured controls. ...

        Research

        Epithelial Mesenchymal Transition in Respiratory Disease: Fact or Fiction

        In this translational review, the mechanisms, roles, and impact of epithelial-mesenchymal transition in chronic lung diseases are discussed ...

        Research

        The plural of anecdote is not data, please mind the gap

        The COVID-19 pandemic introduced challenges to everyone in society but particularly so to every aspect of medical practice. It is bewildering how quickly the profession has had to respond to rapidly changing clinical landscape. Our well-established methods involve collecting and analyzing data to generate an evidence base which is then disseminated and implemented into routine clinical practice. ...

        Research

        Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPD

        We propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes ...

        Research

        Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

        Baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses ...

        Research

        Whole blood transcriptional responses of very preterm infants during late-onset sepsis

        Blood responses in very preterm infants with LOS are characterised by altered host immune responses that appear to reflect unbalanced immuno-metabolic homeostasis ...

        Research

        Global consensus on nutritional rickets: Implications for Australia

        We conclude that updated global recommendations for therapy of nutritional rickets complement previously published position statements for Australia and New Zealand ...

        Research

        Measuring early childhood development with The Early Human Capability Index (eHCI): a reliability and validity study in China

        With the importance of early childhood development more recognized by the international society, low-cost and cross-culturally comparable measures of early childhood development is in great demand, both in China and worldwide. In this study, we aim to test the psychometrics of the Chinese version of The Early Human Capability Index (eHCI), which is designed as a measurement for school readiness in large population. ...

        Research

        Early analysis of the Australian Covid-19 epidemic

        As of 1 May 2020, there had been 6808 confirmed cases of COVID-19 in Australia. Of these, 98 had died from the disease. The epidemic had been in decline since mid-March, with 308 cases confirmed nationally since 14 April. ...

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