Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

We found that BCG, in a mouse model of neonatal polymicrobial sepsis, induced granulocyte colony-stimulating factor (G-CSF) within hours of administration ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Vaccination remains one of the most effective means of reducing the burden of infectious diseases globally. Improving our understanding of the molecular basis for effective vaccine response is of paramount importance if we are to ensure the success of future vaccine development efforts. We applied cutting edge multi-omics approaches to extensively characterize temporal molecular responses following vaccination with hepatitis B virus (HBV) vaccine. Data were integrated across cellular, epigenomic, transcriptomic, proteomic, and fecal microbiome profiles, and correlated to final HBV antibody titres. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

The co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Birth cohort studies provide an invaluable resource for studies of the influence of the fetal environment on health in later life. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Telethon Kids Institute-led research revealing that six out of 10 nicotine free e-cigarette liquids contained nicotine and other potentially harmful chemicals. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2019
• Impact

Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberculosis, HIV, respiratory syncytial virus, and other major infections of global significance. Approaches at rational vaccine design have been limited by our understanding of the immune response to vaccination at the molecular level. Tools now exist to undertake in-depth analysis using systems biology approaches, but to be fully realized, studies are required in humans with intensive blood and tissue sampling. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

The gut microbiome is a well-recognized modulator of host immunity, and its compositions differ between geographically separated human populations. Systemic innate immune responses to microbial derivatives also differ between geographically distinct human populations. However, the potential role of the microbiome in mediating geographically varied immune responses is unexplored. We here applied 16S amplicon sequencing to profile the stool microbiome and, in parallel, measured whole-blood innate immune cytokine responses to several pattern recognition receptor (PRR) agonists among 2-year-old children across biogeographically diverse settings. Microbiomes differed mainly between high- and low-resource environments and were not strongly associated with other demographic factors. We found strong correlations between responses to Toll-like receptor 2 (TLR2) and relative abundances of Bacteroides and Prevotella populations, shared among Canadian and Ecuadorean children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023