Jonathan Asha Dylan Rosemary Janessa Carapetis AM Bowen Barth Wyber Pickering JR AC DB R Dr AM MBBS FRACP FAFPHM PhD FAHMS BA MBBS DCH FRACP PhD ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the evidence and inform prevention and control strategies. The objective of this study is to evaluate the modes of transmission and attack rates of group A streptococcal infection in human populations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

Contemporary data for the global burden of sore throat and group A Streptococcus (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Severe lower leg cellulitis recurrences are frequent, and each episode increases the likelihood of subsequent recurrence and length of hospitalization ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

Severe lower leg cellulitis presents a major burden to the health sector and is increasing with an ageing population ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

To generate contemporary age-specific mortality rates for Indigenous and non-Indigenous Australians aged <65 years who died from rheumatic heart disease between 2013 and 2017, and to ascertain the underlying causes of death of a prevalent RHD cohort aged <65 years who died during the same period. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to prevent Streptococcus pyogenes infection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directly testing protection afforded by different steady state plasma concentrations of penicillin in an established model of experimental human S. pyogenes pharyngitis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted the need for long-acting penicillins to be delivered less frequently, ideally with reduced pain. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

We estimated the global disease prevalence of and mortality due to rheumatic heart disease over a 25-year period ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Rheumatic heart disease in pregnancy persists in First Nations people in Australia and New Zealand and is associated with major cardiac and perinatal morbidity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020