Staphylococcus aureus is a common cause of bacteremia, yet the epidemiology and predictors of poor outcome remain inadequately defined in childhood. ISAIAH (Invasive Staphylococcus aureus Infections and Hospitalizations in children) is a prospective, cross-sectional study of S. aureus bacteremia in children hospitalized in Australia and New Zealand over 24 months. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Acute poststreptococcal glomerulonephritis (APSGN) is an immune complex-induced glomerulonephritis that develops as a sequela of streptococcal infections. This article provides guidelines for the surveillance of APSGN due to group A Streptococcus (Strep A). The primary objectives of APSGN surveillance are to monitor trends in age- and sex-specific incidence, describe the demographic and clinical characteristics of patients with APSGN, document accompanying risk factors, then monitor trends in frequency of complications, illness duration, hospitalization rates, and mortality. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Asha Christopher Tom Bowen Blyth Snelling AC CC T BA MBBS DCH FRACP PhD GAICD OAM MBBS (Hons) DCH FRACP FRCPA PhD BMBS DTMH GDipClinEpid PhD FRACP ...

• Telethon Kids Institute
• Projects

Acute rheumatic fever (ARF) is a multiorgan inflammatory disorder that results from the body's autoimmune response to pharyngitis or a skin infection caused by Streptococcus pyogenes (Strep A). Acute rheumatic fever mainly affects those in low- and middle-income nations, as well as in indigenous populations in wealthy nations, where initial Strep A infections may go undetected. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Christopher Asha André Dr Anita Blyth Bowen Schultz Campbell CC AC AS AC MBBS (Hons) DCH FRACP FRCPA PhD BA MBBS DCH FRACP PhD GAICD OAM MBChB, PhD, ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Staphylococcus aureus is a common cause of community and health care-associated bacteremia, with authors of recent studies estimating the incidence of S aureus bacteremia (SAB) in high-income countries between 8 and 26 per 100 000 children per year. Despite this, <300 children worldwide have ever been randomly assigned into clinical trials to assess the efficacy of treatment of SAB. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

The epidemiology of invasive meningococcal disease has changed over the last decade and there has been an increase in cases caused by serogroup W135, particularly in Indigenous children. Extra‐meningeal and atypical presentations are associated with serogroup W and may delay diagnosis and therefore appropriate treatment. Public and clinician awareness are essential in facilitating effective new vaccine schedule implementation. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

We overview the changing epidemiology of Group A Streptococcus infections and the genetic alterations that accompany the emergence of Group A Streptococcus strains ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

There is a wide spectrum of disease severity in paediatric Staphylococcus aureus bacteraemia ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018