Secondary antibiotic prophylaxis reduces progression of latent rheumatic heart disease (RHD) but not all children benefit. Improved risk stratification could refine recommendations following positive screening. We aimed to evaluate the performance of a previously developed echocardiographic risk score to predict mid-term outcomes among children with latent RHD.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Regular intramuscular (i.m.) benzathine penicillin G (BPG) injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. Patient adherence to IM BPG is poor, largely due to pain, the need for regular injections every 3-4 weeks and health sector delivery challenges in resource-limited settings. There is an urgent need for new approaches for secondary prophylaxis, such as an implant which could provide sustained penicillin concentrations for more than 6 months. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

We outline a series of research initiatives to improve identification of RHD in administrative data thereby contributing to monitoring the RHD burden globally ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

The review built a case for extending simple and cost–effective measures to all countries. Had these recommendations been put into action, significant... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• September 2014

This editorial refers to ‘Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

This study was undertaken to provide a comprehensive examination of rheumatic heart disease mortality rates and trends in Indigenous Australians. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• July 2015

The global burden of non-communicable diseases (NCDs) continues to grow. Although developing settings face fastest growth in incidence, no country is exempt. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• June 2015

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

This review provides an update on the current status of Group A Streptococcus vaccine development, & describes global efforts to accelerate the development... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

Echocardiographic screening for rheumatic heart disease is cost-effective in our context ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• March 2017