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        Research

        Impaired airway epithelial cell responses from children with asthma to rhinoviral infection

        Human rhinovirus infection delays repair and inhibits apoptotic processes in epithelial cells from non-asthmatic and asthmatic children ...

        Research

        Identification of epithelial phospholipase A2 receptor 1 as a potential target in asthma

        PLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization, and airway inflammation ...

        Research

        Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

        We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

        Research

        Hypoallergenic der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy

        More than 50% of allergic patients have house dust mite (HDM) allergy. ...

        Research

        IgE and IgG binding patterns and T-cell recognition of fel d 1 and Non-Fel d 1 cat allergens

        To compare IgE and IgG antibody binding and T-cell recognition of the major cat allergen Fel d 1 with other cat proteins with known IgE binding properties. ...

        Research

        Longer duration of exclusive breastfeeding associated with reduced risk of childhood asthma up to age six

        Breastfeeding is recommended for all infants irrespective of atopic heredity, although epidemiological studies provide conflicting results in this debate. ...

        Research

        Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

        The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

        Research

        Vitamin D and atopy and asthma phenotypes in children

        The purpose of this Review was to give an overview of the recent research into whether a lack of vitamin D contributes to the development of atopy and asthma... ...

        Research

        Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways

        nfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation.  ...

        News & Events

        Vitamin D deficiency linked to childhood asthma

        Researchers at the Telethon Kids Institute have found children with vitamin D deficiency are more likely to develop asthma. ...

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