A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Iron deficiency (ID) is the most common nutritional deficiency affecting young children. Serum ferritin concentration is the preferred biomarker for measuring iron status because it reflects iron stores; however, blood collection can be distressing for young children and can be logistically difficult. A noninvasive means to measure iron status would be attractive to either diagnose or screen for ID in young children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

This study aims to understand the experience and impact of the initial COVID-19 lock-down in young families with children aged below 4 years. Free text questions were administered to participants in the ORIGINS (Australia) and Born in Bradford (UK) cohort studies to collect qualitative information on worries, concerns and enjoyable experiences during the pandemic. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

This study explores how the first wave of the COVID‐19 pandemic influenced family routines, relationships and technology use (smartphones and tablet computers) among families with infants. Infancy is known to be an important period for attachment security and future child development, and a time of being susceptible to changes within and outside of the family unit. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

Bold new approaches are urgently needed to overcome global health challenges. The proposed Advanced Research Projects Agency for Health (ARPA-H) is intended to provide rapid health breakthroughs. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

The Childhood Allergy and Immunology Research Team at the Telethon Kids Institute are currently conducting four studies, through The ORIGINS Project, investigating nutritional strategies in the diets of mothers and babies and how these may reduce the development of allergies. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2020
• June

Research data from more than one million Australian and Welsh children will be examined to help better understand how the built environment affects child health and obesity, as part of an international research project to be co-led by the Telethon Kids Institute. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2020
• June

Investigating the possible contributors to childhood lung disease by studying the epithelial cells from the nose at birth. ...

• The ORIGINS Project
• Sub-projects
• Allergy, Inflammation & Immunity

Testosterone and Language in Kids ...

• The ORIGINS Project
• Sub-projects
• Brain & Behaviour

ORIGINS has sub-projects exploring the link between a mother's diet during pregnancy and health outcomes of the child. Projects also explore nutrition and eating habits during the early years. ...

• The ORIGINS Project
• Sub-projects