The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• July 2014

B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by diverse genomic alterations, the most frequent being gene fusions detected via transcriptomic analysis (mRNA-seq). Due to its hypervariable nature, gene fusions involving the Immunoglobulin Heavy Chain (IGH) locus can be difficult to detect with standard gene fusion calling algorithms and significant computational resources and analysis times are required. We aimed to optimize a gene fusion calling workflow to achieve best-case sensitivity for IGH gene fusion detection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

This study examines whether polymorphisms in the ERBB2 gene were associated with leprosy in primary and replication cohorts from northeastern Brazil. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

An optimized, rapid method for creating markerless isogenic mutations that combines Gibson assembly cloning with a new temperature-sensitive plasmid, pLZts ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(O ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• October 2010

We assessed 30 sibships and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations with polymorphisms in the NOD2 gene. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

The MACROD2 gene is a strong positional candidate risk factor for autistic-like traits in the general population ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukaemia (ALL). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

The effect of breast-feeding on the development of allergic disease is uncertain ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011