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        11-20 of 42 results for 'Peter Le souef'

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        Research

        TLR3 and RIG-I gene variants: Associations with functional effects on receptor expression and responses to measles viru

        Measles virus causes severe morbidity and mortality, despite the availability of measles vaccines. Successful defence against viral pathogens requires early... ...

        Research

        Rhinoviruses A and C elicit long-lasting antibody responses with limited cross-neutralization

        Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood. Based on those findings, we hypothesized that RV-C infections are more likely to induce either cross-neutralizing or longer-lasting antibody responses compared with RV-A infections. ...

        News & Events

        20-year MAVRIC study celebrates recruitment of its 1000th participant

        The MAVRIC (Mechanisms of Acute Viral Respiratory Infection in Children) study recently celebrated the recruitment of the 1000th participant to the study, eight-year-old Sullivan Strahan. ...

        Research

        Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze

        Ingrid Pat Laing Holt IL PG BSc PhD PhD, DSc, FRCPath, FRCPI, FAA Head, Children's Respiratory Science Emeritus Honorary Researcher 6319 1828 ...

        Research

        Mechanisms of Acute Viral Respiratory Illness in Children (MAVRIC)

        Ingrid Anthony Deborah Jonatan Thomas Laing Kicic Strickland Leffler Iosifidis IL A DH JL TI BSc PhD BSc (Hons) PhD PhD PhD BSc BMedSci(Hons) PhD ...

        Research

        Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique

        We investigated IL-4, IL-13, and IL-4Rα polymorphisms and their impact on measles IgG responses and measles vaccine failure, in two separate cohort. ...

        Research

        Impact of CD14 promoter variants on measles vaccine responses and vaccine failure in children from Australia and Mozambique

        Host genetics are likely to play a crucial role, particularly variants that alter key innate immune response genes. ...

        Research

        CD46 measles virus receptor polymorphisms influence receptor protein expression

        Despite the availability of measles vaccines, infants continue to die from measles. Measles vaccine responses vary between individuals, and poor... ...

        Research

        Toll-like receptor 7 and 8 polymorphisms: Associations with functional effects and cellular and antibody responses to measles virus and vaccine

        The functionality and effects of TLR7 and TLR8 polymorphisms on cellular and antibody responses was investigated after the first measles vaccine dose. ...

        News & Events

        Wal-yan Centre inaugural Shark Tank winners

        Congratulations to Dr Montgomery, Dr Iosifidis and Dr D’Vaz on winning the Wal-yan Centre's inaugural seed funding competition. ...

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