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        Research

        Cardiovascular disease risk factor profiles of 263,356 older Australians according to region of birth

        Risk factors for cardiovascular disease (CVD), such as obesity, diabetes, hypertension and physical inactivity, are common in Australia, but the prevalence... ...

        Research

        Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling

        Progesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, rapid acute induction of PGR is the key determinant of ovulation through transcriptional control of a unique set of genes that culminates in follicle rupture. However, the molecular mechanisms for this specialized PGR function in ovulation is poorly understood. ...

        Research

        Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians

        This is the largest collection of normative T LCO data, and the first global reference values available for T LCO. ...

        Research

        Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma

        Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells. ...

        Research

        Defective respiratory tract immune surveillance in asthma : A primary causal factor in disease onset and progression

        The relative importance of respiratory viral infections vs inhalant allergy in asthma pathogenesis is the subject of ongoing debate. ...

        Research

        High expression of connective tissue growth factor accelerates dissemination of leukaemia

        Functional role of CTGF in altering disease progression in a lymphoid malignancy ...

        Research

        A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults:

        Neisseria meningitidis is a leading cause of meningitis and septicaemia, but a broadly-protective vaccine against endemic serogroup B disease is not licensed... ...

        Research

        Deregulated expression of connective tissue growth factor is linked to poor outcome in human cancer

        Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific. ...

        Research

        Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

        Study the innate immune function in ulcerative colitis patients who fail to respond to anti-tumor necrosis factor therapy ...

        Research

        The factor structure of the eating disorder examination in clinical and community samples

        We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes ...

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